Research Articles
Cancer Stem Cells: Decoding Their Central Role in Tumor Heterogeneity and Therapeutic Resistance
Cancer stem cells (CSCs) are a pivotal subpopulation driving tumor initiation, progression, and relapse due to their self-renewal capacity, differentiation potential, and profound resistance to conventional therapies.
Validation of Biomarkers to Predict Immunotherapy Response: A Comprehensive Guide from Discovery to Clinical Application
This article provides a comprehensive roadmap for researchers and drug development professionals on the validation of predictive biomarkers for cancer immunotherapy.
Comparative Performance of PD-L1 Immunohistochemistry Assays: A Critical Analysis for Researchers and Drug Developers
This article provides a comprehensive analysis of the comparative performance of various PD-L1 immunohistochemistry (IHC) assays, a critical predictive biomarker for immune checkpoint inhibitor response.
Ensuring Equity in Early Detection: A Comprehensive Guide to Validating Cancer Risk Models Across Diverse Populations
This article addresses the critical challenge of validating cancer risk prediction models across racially, ethnically, and geographically diverse populations—a prerequisite for equitable clinical application.
Comparative Analysis of Molecular Techniques in Cancer Diagnostics: From Foundational Methods to AI-Integrated Platforms
This comprehensive review systematically compares established and emerging molecular techniques for cancer diagnostics, addressing the needs of researchers, scientists, and drug development professionals.
Mechanistic Models vs. AI in Tumor Modeling: A New Paradigm for Computational Oncology
This article provides a comprehensive analysis for researchers and drug development professionals on the distinct yet complementary roles of mechanistic models and artificial intelligence (AI) in computational oncology.
Foundation Models vs. Traditional Transfer Learning in Computational Pathology: A New Paradigm for Precision Oncology
The emergence of foundation models is fundamentally reshaping the artificial intelligence landscape in computational pathology.
Automated Breast Ultrasound vs. Mammography: A Comparative Analysis for Enhanced Cancer Detection and Screening
This article provides a comprehensive comparison between traditional mammography and automated breast ultrasound (ABUS) for breast cancer screening, with a focus on implications for clinical research and diagnostic development.
dPCR vs qPCR for Mutant Allele Detection: A Strategic Guide for Precision Analysis
This article provides a comprehensive comparison of digital PCR (dPCR) and quantitative PCR (qPCR) for the detection and quantification of mutant alleles, a critical task in oncology, biomarker validation, and...
Analytical Validation of PD-L1 Assays: A Comprehensive Guide for Clinical Implementation and Biomarker Development
This article provides a comprehensive resource for researchers, scientists, and drug development professionals on the analytical validation of PD-L1 assays for clinical use.